A new modeling approach allowing prediction and comparison of the long-term outcomes of treatments for hemophilia B.


AIM To develop a modeling approach to compare clinical outcomes of nonacog beta pegol to a standard-acting factor IX (FIX) product. METHODS Regression analysis linked FIX activity to bleed rates. Pharmacokinetic parameters were used to estimate FIX activity over time. The probability of bleeds was estimated for both treatment arms. A Markov model… (More)
DOI: 10.2217/cer-2017-0028


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