A new model of visceral pain and referred hyperalgesia in the mouse

@article{Laird2001ANM,
  title={A new model of visceral pain and referred hyperalgesia in the mouse},
  author={Jennifer M. A. Laird and Leticia Mart{\'i}nez-Caro and Esther Garc{\'i}a-Nicas and Fernando Cervero},
  journal={PAIN®},
  year={2001},
  volume={92},
  pages={335-342}
}
The generation of transgenic mice that lack or overexpress genes relevant to pain is becoming increasing common. However, only one visceral pain model, the writhing test, is widely used in mice. Here we describe a novel model, chemical stimulation of the colon, which we have developed in mice. Mice of either sex were injected i.v. with 30 mg/kg Evan's Blue for subsequent determination of plasma extravasation. For behavioural testing, they were placed on a raised grid and 50 microl of saline… CONTINUE READING
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