A new model of duodenal ulcers induced in rats by indomethacin plus histamine.

@article{Takeuchi1986ANM,
  title={A new model of duodenal ulcers induced in rats by indomethacin plus histamine.},
  author={Koji Takeuchi and Osamu Furukawa and Hironori Tanaka and Susumu Okabe},
  journal={Gastroenterology},
  year={1986},
  volume={90 3},
  pages={636-45}
}
We standardized a new method for producing duodenal ulcers in rats by administering indomethacin plus histamine, and investigated the pathogenesis. Indomethacin (5 mg/kg) was first given subcutaneously to rats fasted for 24 h, and subsequently histamine dihydrochloride (40 mg/kg) was given subcutaneously three times, at 2.5-h intervals, beginning 30 min after injection of indomethacin. This combined treatment induced one or two round lesions (9.8 +/- 1.4 mm2) in the proximal duodenum at an… CONTINUE READING