A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics.

  title={A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics.},
  author={Anthony Marmarou and Montasser A. Foda and Willem A. van den Brink and J K Campbell and H Kita and K Demetriadou},
  journal={Journal of neurosurgery},
  volume={80 2},
This report describes the development of an experimental head injury model capable of producing diffuse brain injury in the rodent. A total of 161 anesthetized adult rats were injured utilizing a simple weight-drop device consisting of a segmented brass weight free-falling through a Plexiglas guide tube. Skull fracture was prevented by cementing a small stainless-steel disc on the calvaria. Two groups of rats were tested: Group 1, consisting of 54 rats, to establish fracture threshold; and… 

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  • 1969
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