A new model of diabetic nephropathy in C57BL/6 mice challenged with advanced oxidation protein products.

@article{Bai2018ANM,
  title={A new model of diabetic nephropathy in C57BL/6 mice challenged with advanced oxidation protein products.},
  author={Xiaoyan Bai and Xiao Li and Jianwei Tian and Liting Xu and Jiao Wan and Youhua Liu},
  journal={Free radical biology & medicine},
  year={2018},
  volume={118},
  pages={71-84}
}
There remains a lack of robust mouse models with key features of advanced human diabetic nephropathy (DN). Few options of murine models of DN require mutations to be superimposed to obtain desired phenotypic characteristics. Most genetically modified mice are on the C57BL/6 background; however, they are notorious for resistance to develop DN. To overcome… CONTINUE READING