A new model of cortical stroke in the rhesus macaque.

@article{West2009ANM,
  title={A new model of cortical stroke in the rhesus macaque.},
  author={G. Alexander West and Kiarash J. Golshani and Kristian P Doyle and Nikola S Lessov and Theodore R. Hobbs and Steven G. Kohama and Martin M. Pike and Christopher D. Kroenke and Marjorie R. Grafe and M. D. Spector and E. Testart Tobar and Roger Pancoast Simon and Mary P. Stenzel-Poore},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2009},
  volume={29 6},
  pages={
          1175-86
        }
}
Primate models are essential tools for translational research in stroke but are reportedly inconsistent in their ability to produce cortical infarcts of reproducible size. Here, we report a new stroke model using a transorbital, reversible, two-vessel occlusion approach in male rhesus macaques that produces consistent and reproducible cortical infarcts. The right middle cerebral artery (distal to the orbitofrontal branch) and both anterior cerebral arteries were occluded with vascular clips… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2008
VIEW 1 EXCERPT

Evidence of the peripheral inflammatory response in patients with transient ischemic attack.

  • Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • 2007
VIEW 1 EXCERPT