A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat.

@article{Nissinen2000ANM,
  title={A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat.},
  author={Jari Nissinen and Toivo Halonen and Esa H Koivisto and Asla Pitk{\"a}nen},
  journal={Epilepsy research},
  year={2000},
  volume={38 2-3},
  pages={177-205}
}
Spontaneous seizures are the hallmark of human epilepsy but they do not occur in most of the epilepsy models that are used to investigate the mechanisms of epilepsy or to test new antiepileptic compounds. This study was designed to develop a new focal epilepsy model that mimics different aspects of human temporal lobe epilepsy (TLE), including the occurrence of spontaneous seizures. Self-sustained status epilepticus (SSSE) lasting for 6-20 h was induced by a 20-30 min stimulation of the lateral… CONTINUE READING
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