A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F

@article{Liu1998ANM,
  title={A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F},
  author={Ningshu Liu and F. C. Lucibello and Kurt Engeland and Rolf M{\"u}ller},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={2957-2963}
}
Cell cycle regulation of the cyclin A gene is determined by a bipartite repressor binding site in the region of the basal promoter, termed CDE-CHR, which also controls the expression of cell cycle genes upregulated in S or G2 (such as cdc25C). The CDE–CHR in the cyclin A promoter is recognized by both E2F complexes and CDF-1, but the contribution of each of these factors in cell cycle regulation is unknown. In the present study, we have introduced mutations into the cyclin A promoter which lead… CONTINUE READING
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