A new model of busulphan-induced chronic bone marrow aplasia in the female BALB/c mouse.

@article{Gibson2003ANM,
  title={A new model of busulphan-induced chronic bone marrow aplasia in the female BALB/c mouse.},
  author={Frances M Gibson and Charles M Andrews and Paraskevi Diamanti and Si{\^a}n Rizzo and George Macharia and Edward C Gordon-Smith and Thomas Christie Williams and John Turton},
  journal={International journal of experimental pathology},
  year={2003},
  volume={84 1},
  pages={31-48}
}
Aplastic anaemia (AA) is characterized by hypocellular marrow, pancytopenia, and risk of severe anaemia, haemorrhage and infection. AA is often idiopathic, but frequently occurs after exposure to drugs/chemicals. However, the pathogenesis of AA is not clearly understood, and there are no convenient animal models of drug-induced AA. We have evaluated regimens of busulphan (BU) administration in the mouse to produce a model of chronic bone marrow aplasia showing features of human AA. Mice were… CONTINUE READING