A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling.

@article{Shirai2006ANM,
  title={A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling.},
  author={Kumi Shirai and Shizuya Saika and Takeshi Tanaka and Yuka Okada and Kathleen C. Flanders and Akira Ooshima and Yoshitaka Ohnishi},
  journal={Molecular vision},
  year={2006},
  volume={12},
  pages={681-91}
}
PURPOSE To develop a new animal model of anterior subcapsular cataract formation by topical application of alkali to the eye and to examine the role of Transforming growth factorbeta/Smad3 (TGFbeta/Smad3) signaling in the formation of this cataract model. METHODS Under anesthesia, one eye of adult Wistar rats (n=142) was subjected to alkali burn by topical application of 1 N NaOH. The eye was then histologically examined at specific time intervals. Immunohistochemistry with a battery of… CONTINUE READING