A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling.

Abstract

PURPOSE To develop a new animal model of anterior subcapsular cataract formation by topical application of alkali to the eye and to examine the role of Transforming growth factorbeta/Smad3 (TGFbeta/Smad3) signaling in the formation of this cataract model. METHODS Under anesthesia, one eye of adult Wistar rats (n=142) was subjected to alkali burn by… (More)

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@article{Shirai2006ANM, title={A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling.}, author={Kumi Shirai and Shizuya Saika and Takeshi Tanaka and Yuka Okada and Kathleen C. Flanders and Akira Ooshima and Yoshitaka Ohnishi}, journal={Molecular vision}, year={2006}, volume={12}, pages={681-91} }