A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8(+) T-cell responses.

@article{Araki2004ANM,
  title={A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8(+) T-cell responses.},
  author={Koichi Araki and K Yoshimatsu and B. Lee and Hiroaki Kariwa and Ikuo Takashima and Jiro Arikawa},
  journal={Virology},
  year={2004},
  volume={322 2},
  pages={318-27}
}
We established a viral persistence model that involves the adoptive transfer of spleen cells from immunocompetent mice (H-2(d)) into Hantaan virus (HTNV)-infected severe combined immunodeficient (SCID, H-2(d)) mice. The infection is maintained despite the presence of neutralizing antibodies, without apparent signs of disease, and there is a correlation between HTNV persistence and the lack of HTNV-specific CD8(+) T cells. In addition, disseminated HTNV infection before the initiation of immune… CONTINUE READING
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