A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.

Abstract

Vitamin K-dependent (VKD) proteins require carboxylation for diverse functions that include hemostasis, apoptosis, and Ca(2+) homeostasis, yet the mechanism of carboxylation is not well understood. Combined biochemical and chemical studies have led to a long-standing model in which a carboxylase Cys catalytic base deprotonates vitamin K hydroquinone (KH(2… (More)

Topics

7 Figures and Tables

Cite this paper

@article{Rishavy2004ANM, title={A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.}, author={Mark A Rishavy and B Nirmala Pudota and Kevin Hallgren and Wen Hua Qian and Anna V Yakubenko and Jee-Hyeon Song and Kurt W Runge and Kathleen L. Berkner}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2004}, volume={101 38}, pages={13732-7} }