A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.

@article{Sengle2008ANM,
  title={A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.},
  author={Gerhard Sengle and Robert N. Ono and Karen M Lyons and Hans Peter Baechinger and Lynn Yasuko Sakai},
  journal={Journal of molecular biology},
  year={2008},
  volume={381 4},
  pages={
          1025-39
        }
}
Bone morphogenetic proteins (BMPs) are morphogens with long-range signaling activities. BMP-7 is secreted as a stable complex consisting of a growth factor noncovalently associated with two propeptides. In other transforming growth factor-beta-like growth factor complexes, the prodomain (pd) confers latency to the complex. However, we detected no difference in signaling capabilities between the growth factor and the BMP-7 complex in multiple in vitro bioactivity assays. Biochemical and… CONTINUE READING
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