A new middle cerebral artery occlusion model for intra-arterial drug infusion in rats

@article{Sun2015ANM,
  title={A new middle cerebral artery occlusion model for intra-arterial drug infusion in rats},
  author={Wen-hao Sun and Hui-sheng Chen},
  journal={Neuroscience Letters},
  year={2015},
  volume={607},
  pages={102-107}
}
With the wide application of intra-arterial therapy for cerebrovascular disorders, preclinical intra-arterial drug-delivery studies based on middle cerebral artery occlusion (MCAO) models have become urgent. In the present study, a novel stroke model was developed for intra-arterial drug delivery: MCAO and drug delivery were accomplished using a microcatheter device. MCAO was induced in Sprague-Dawley rats using the microcatheter device (cMCAO group, n=10) or a nylon suture (sMCAO group, n=10… CONTINUE READING

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