A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system.

@article{Burchell1988ANM,
  title={A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system.},
  author={Ann Burchell and Robert Hume and Brian Burchell},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1988},
  volume={173 2},
  pages={183-91}
}
A microtechnique has been developed which enables a complete kinetic analysis of the human hepatic microsomal glucose-6-phosphatase system to be carried out in microsomes isolated from very small liver samples. Complete or partial deficiencies of any of the proteins of the glucose-6-phosphatase system resulting in Type 1a, 1b, 1c or 1d glycogen storage disease can be therefore be diagnosed using hepatic needle biopsy samples, whereas previous methods of diagnosis needed large wedge biopsy… CONTINUE READING