A new method to measure type I and III collagen synthesis in human skin in vivo: demonstration of decreased collagen synthesis after topical glucocorticoid treatment.

@article{Oikarinen1992ANM,
  title={A new method to measure type I and III collagen synthesis in human skin in vivo: demonstration of decreased collagen synthesis after topical glucocorticoid treatment.},
  author={Aarne Oikarinen and Pekka Autio and U O Kiistala and Leila Risteli and Juha P Risteli},
  journal={The Journal of investigative dermatology},
  year={1992},
  volume={98 2},
  pages={220-5}
}
Collagen is synthesized as procollagen and large extra domains known as propeptides are cleaved off enzymatically. In the present study we have measured the carboxyterminal propeptide of type I collagen (PICP) and the aminoterminal propeptide of type III collagen (PIIINP) in blister fluids of human skin. High concentrations of PICP were found in the… CONTINUE READING