A new method for the deprotection of benzyl ethers or the selective protection of alcohols

@article{Madsen2000ANM,
  title={A new method for the deprotection of benzyl ethers or the selective protection of alcohols},
  author={Madsen and Viuf and Bols},
  journal={Chemistry},
  year={2000},
  volume={6 7},
  pages={1140-6}
}
A new selective method for the deprotection of benzyl ethers situated next to alcohols in the alpha, beta, or gamma position is presented which uses either NIS or DIB/I2 as a reagent. After initial formation of a hypoiodite intermediate, the reaction is believed to follow a radical pathway to resemble the Hoffman-Loffler-Freytag reaction. The formation of… CONTINUE READING