A new method for measuring functional similarity of microRNAs

  title={A new method for measuring functional similarity of microRNAs},
  author={Guangchuang Yu and Chuan-le Xiao and Xiaochen Bo and Chun-hua Lu and Yide Qin and Sheng Zhan and Qing‐Yu He},
MicroRNAs (miRNAs) are a group of small RNAs with regulatory roles at post-transcriptional level. Although they have been clustered based on their sequence or structure similarities, there is still no effective method to determine their functional similarities due to the lack of miRNAs functional annotation. To address this critical need, we presented here a novel  method for systematic study of functional similarities among human miRNAs by using their target genes GO semantic similarities. The… 

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