A new method for high-performance liquid chromatographic determination of drotaverine in plasma.

@article{Mezei1984ANM,
  title={A new method for high-performance liquid chromatographic determination of drotaverine in plasma.},
  author={J. Mezei and S. K{\"u}ttel and P. Szentmiklosi and S. Marton and I. R{\'a}cz},
  journal={Journal of pharmaceutical sciences},
  year={1984},
  volume={73 10},
  pages={
          1489-91
        }
}
A sensitive, specific high-performance liquid chromatographic procedure was developed for the determination of plasma drotaverine levels. Basic plasma samples were adjusted to pH 1.5 and extracted with chloroform. HPLC [n-heptane-dichloromethane-diethylamine (50:25:2)] on a microporous silica column, with a variable-wavelength UV detector set at 302 nm allowed the measurement of drotaverine at the 50-ng/mL level. The utility of this method for determination of drotaverine in dog and rat plasma… Expand
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References

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