A new method for drug transport studies on pig nasal mucosa using a horizontal Ussing chamber.

@article{Osth2002ANM,
  title={A new method for drug transport studies on pig nasal mucosa using a horizontal Ussing chamber.},
  author={Karin Osth and Johan Gr{\aa}sj{\"o} and Erik Bj{\"o}rk},
  journal={Journal of pharmaceutical sciences},
  year={2002},
  volume={91 5},
  pages={1259-73}
}
The horizontal Ussing chamber method described here allows performance of transport studies on pig nasal respiratory mucosa under conditions simulating reality in that it mimics the air-mucosa interface. The transport of testosterone and mannitol through pig nasal mucosa in the horizontal Ussing chamber was investigated using both liquid and air mucosal interfaces. There were no significant differences in either the bioelectrical parameters (transmucosal electrical resistance, R, potential… CONTINUE READING

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