A new method for assessing metronidazole susceptibility of Giardia lamblia trophozoites.

@article{Sousa1999ANM,
  title={A new method for assessing metronidazole susceptibility of Giardia lamblia trophozoites.},
  author={Maria do C{\'e}u Sousa and J Poiares-da-Silva},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 12},
  pages={2939-42}
}
A quantitative, simple, and rapid assay has been developed to assess Giardia lamblia trophozoite sensitivity to metronidazole [1-(2-hydroxyetyl)-2-methyl-5-nitroimidazole] (MTZ). This new assay utilizes the ability of live (surviving) trophozoites to take up oxygen after have been exposed to MTZ. The effect of MTZ on oxygen uptake was compared with its effect on viability as evaluated by a culture method and morphological assays. Oxygen uptake rates decreased in trophozoites treated with MTZ… CONTINUE READING

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