A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

@article{Akimoto1994ANM,
  title={A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.},
  author={Kazunori Akimoto and Kouichi Mizuno and S. Osada and Shinobu Hirai and Sei-ichi Tanuma and Keiichiro Suzuki and Shigeo Ohno},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 17},
  pages={12677-83}
}
Protein kinase C (PKC)-related cDNA clones isolated from cDNA libraries of mouse P19 embryonal carcinoma cells and mouse brain encoded a 67-kDa protein, PKC lambda. PKC lambda shows the highest amino acid sequence identity with PKC zeta (72%), the third class of the PKC family. Northern blot analysis showed that the mRNA for PKC lambda is expressed in a wide variety of cells and tissues, including P19 and NIH 3T3 cells, as well as brain, kidney, testis, and ovary. In undifferentiated P19 cells… CONTINUE READING
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