A new member of the immunoglobulin superfamily—CTLA-4

  title={A new member of the immunoglobulin superfamily—CTLA-4},
  author={J J Brunet and François Denizot and M G Luciani and Magali Roux-Dosseto and Marie Suzan and Marie-Genevi{\`e}ve Mattei and Pierre Golstein},
The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains1,2. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) class I and class II and T-cell receptor (TCR) molecules. Several members of this superfamily are expressed on lymphocytes where they are membrane-bound and capable of… CONTINUE READING
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