A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain.

@article{Ito1997ANM,
  title={A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain.},
  author={Ken-ichi Ito and Mark Groudine},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 42},
  pages={26780-6}
}
We have isolated and characterized a novel member (CAT3) of the cationic amino acid transporter (CAT) family. In oocyte injection assays, CAT3 cRNA exhibited a saturable, sodium ion-independent transport activity with high affinity for L-arginine and L-lysine (Km = 40-60 and 115-165 microM, respectively). Transport of L-arginine was effectively competed only by cationic amino acids in L-form: arginine, lysine, ornithine, and 2,4-diamino-n-butyric acid but not by 2,3-diaminopropionic acid. The… CONTINUE READING

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