A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase.

Abstract

Mitomycin C (MMC) is a chemotherapeutic drug that requires an enzymatic bioreduction to exert its biological effects. Upon reduction, MMC is converted into a highly reactive bis-electrophilic intermediate that alkylates cellular nucleophiles. Alkylation of DNA is the most favored mechanism of action for MMC, but other modes of action, such as redox cycling… (More)
DOI: 10.1021/tx3002065

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