A new measure for functional similarity of gene products based on Gene Ontology

@article{Schlicker2006ANM,
  title={A new measure for functional similarity of gene products based on Gene Ontology},
  author={Andreas Schlicker and Francisco S. Domingues and J{\"o}rg Rahnenf{\"u}hrer and Thomas Lengauer},
  journal={BMC Bioinformatics},
  year={2006},
  volume={7},
  pages={302 - 302}
}
Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods that compare gene products regarding their molecular function and biological role. We present a new method for comparing sets of GO terms and for assessing the functional similarity of gene products. The method relies on two semantic similarity measures; sim Rel and funSim. One measure (sim Rel ) is applied in the comparison of… CONTINUE READING
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