A new marker at DXS 115 useful for carrier detection in hemophilia A

@article{Wehnert1990ANM,
  title={A new marker at DXS 115 useful for carrier detection in hemophilia A},
  author={Manfred S. Wehnert and W. Christopher Schroeder and Falko H. Herrmann},
  journal={Human Genetics},
  year={1990},
  volume={86},
  pages={59-60}
}
In this brief communication we report a new intergenic polymorphism at DXS115 as a marker for detection of heterozygotes in families at risk for hemophilia A. Total genomic DNA was isolated from white blood cells, double digested by KpnI and XbaI and hybridized with EcoRI/SstI fragment of the genomic probe p482.6. The incidence of the polymorphic 5.1-kb fragment was estimated as 0.069 in a German population. A technical advantage of using the XbaI/KpnI RFLP is that both the intragenic XbaI-RFLP… CONTINUE READING

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An intronic region within the human factor Vlll gene is duplicated within Xq28 and is homologous to the polymorphic locus DXSII5 (767)

  • J Patterson M. Gitschier, M Bloomfield J. Bell, H Dorkins, U Froster-lskenius, J Sommer S. Sobell, KE Schaid D. Thibodcau S. Davies
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Genetic mapping of the Xq27-q28 region: new RFLP markers useful for diagnostic applications in fragile X and hemophilia-B families

  • S Arveiler, I Oberl, A Vincent, MH Hofker, PL Pearson, JL Mandel
  • Am J Hum Genet
  • 1988

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