A new look at blood coagulation factor V.

  title={A new look at blood coagulation factor V.},
  author={Rodney M. Camire},
  journal={Current opinion in hematology},
  volume={18 5},
PURPOSE OF REVIEW Factor V plays an essential role in hemostasis and has a profound influence on thrombin generation. The aim of this review is to highlight recent advances in our understanding of the biology of factor V which shed light on the variable bleeding tendencies in severe factor V deficiency. Furthermore, new mechanistic insights responsible for maintaining factor V as an inactive procofactor will be discussed. RECENT FINDINGS The bleeding manifestation of severe factor V-deficient… CONTINUE READING