A new locus for inherited nuclear cataract mapped to the long arm of chromosome 1.


PURPOSE To identify the disease-associated locus in a Chinese family with autosomal-dominant inherited nuclear cataract. METHODS Genomic DNAs were obtained from 17 family members in a four-generation Chinese family, who had eight members affected with cataract. Exclusive linkage analysis of known candidate inherited cataract loci was performed. A genome… (More)