A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis

@article{Han2012ANI,
  title={A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis},
  author={Sang Jun Han and Shannon M Hawkins and Khurshida Begum and Sung Yun Jung and Ertug Kovanci and Jun Qin and John P. Lydon and Francesco J. Demayo and Bert W O'malley},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={1102-1111}
}
Endometriosis is considered to be an estrogen-dependent inflammatory disease, but its etiology is unclear. Thus far, a mechanistic role for steroid receptor coactivators (SRCs) in the progression of endometriosis has not been elucidated. An SRC-1–null mouse model reveals that the mouse SRC-1 gene has an essential role in endometriosis progression. Notably, a previously unidentified 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with surgically… CONTINUE READING
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