A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode.

@article{Chen2009ANI,
  title={A new isoform of interleukin-3 receptor \{alpha\} with novel differentiation activity and high affinity binding mode.},
  author={Jinglong Chen and Jane E Olsen and Sally C. Ford and Shamaruh Mirza and Andrew B Walker and James M Murphy and Ian G. Young},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 9},
  pages={5763-73}
}
Interleukin-3 (IL-3) promotes both self-renewal and differentiation of early multipotential progenitors and is involved in inducible hematopoiesis in response to infections. Here we report new insights into these processes with the identification of a new isoform (SP2) of IL-3 receptor alpha (IL-3Ralpha), present in mouse and human hematopoietic cells, which lacks domain 1 of the full-length receptor (SP1). Binding assays with beta(IL-3) mutants showed that mouse SP2 uses a different high… CONTINUE READING

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