A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls.

@article{JessenEller2002ANI,
  title={A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls.},
  author={Kathryn Jessen-Eller and Jill A. Kreiling and Gail S Begley and M Elizabeth Steele and C. Wayne Walker and Raymond E Stephens and Carol L. Reinisch},
  journal={Environmental Health Perspectives},
  year={2002},
  volume={110},
  pages={377 - 385}
}
The cell-cycle checkpoint protein p53 both directs terminal differentiation and protects embryos from DNA damage. To study invertebrate p53 during early development, we identified three differentially expressed p53 family members (p53, p97, p120) in the surf clam, Spisula solidissima. In these mollusks, p53 and p97 occur in both embryonic and adult tissue, whereas p120 is exclusively embryonic. We sequenced, cloned, and characterized p120 cDNA. The predicted protein, p120, resembles p53 across… CONTINUE READING
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