A new interpretation of antiestrogen action.

  title={A new interpretation of antiestrogen action.},
  author={Annemarie Hedden and Volkmar Mueller and Elwood V. Jensen},
  journal={Annals of the New York Academy of Sciences},
Despite differences in their pharmacological behavior, type I and type II antiestrogens have certain important properties in common. Both differ from estradiol in that they enhance the immunoreactivity of estrogen receptors, apparently by inducing conformational change that exposes an additional epitope for a particular monoclonal antibody. Moreover, both types of antihormones not only compete with estradiol for its binding to the receptor but they also react with another domain not recognized… CONTINUE READING