A new interferon, limitin, displays equivalent immunomodulatory and antitumor activities without myelosuppressive properties as compared with interferon-alpha.

Abstract

OBJECTIVE Limitin is a new member of type I interferon (IFN) identified with an expression cloning based on the growth suppression of a myelomonocytic leukemia cell line WEHI3. Although limitin uses the IFN-alpha/beta receptor, its signal transduction pathways to express the antiviral effects are different from those of IFN-alpha. To clarify the… (More)

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Cite this paper

@article{Kawamoto2004ANI, title={A new interferon, limitin, displays equivalent immunomodulatory and antitumor activities without myelosuppressive properties as compared with interferon-alpha.}, author={Shin-ichiro Kawamoto and Kenji Oritani and Eiji Asakura and Jun Ishikawa and Mamoru Koyama and Kenmi Miyano and Minori Iwamoto and Shin-ichiro Yasuda and Hirosi Nakakubo and Fumihiro Hirayama and Naoko Ishida and Hidetoshi Ujiie and Hiroaki Masaie and Yoshiaki Tomiyama}, journal={Experimental hematology}, year={2004}, volume={32 9}, pages={797-805} }