A new insight into mushroom tyrosinase inhibitors: docking, pharmacophore-based virtual screening, and molecular modeling studies

@article{Bagherzadeh2015ANI,
  title={A new insight into mushroom tyrosinase inhibitors: docking, pharmacophore-based virtual screening, and molecular modeling studies},
  author={Kowsar Bagherzadeh and Faezeh Shirgahi Talari and Amirhossein Sharifi and Mohammad Reza Ganjali and Ali Akbar Saboury and Massoud Amanlou},
  journal={Journal of Biomolecular Structure and Dynamics},
  year={2015},
  volume={33},
  pages={487 - 501}
}
Tyrosinase, a widely spread enzyme in micro-organisms, animals, and plants, participates in two rate-limiting steps in melanin formation pathway which is responsible for skin protection against UV lights’ harm whose functional deficiency result in serious dermatological diseases. This enzyme seems to be responsible for neuromelanin formation in human brain as well. In plants, the enzyme leads the browning pathway which is commonly observed in injured tissues that is economically very… 
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