A new infectious mammary tumor virus in the milk of mice implanted with C4 hyperplastic alveolar nodules.

@article{Shakhov1993ANI,
  title={A new infectious mammary tumor virus in the milk of mice implanted with C4 hyperplastic alveolar nodules.},
  author={A. N. Shakhov and H Wang and Hans Acha-Orbea and Robert J. Pauley and Wei Wei},
  journal={European journal of immunology},
  year={1993},
  volume={23 11},
  pages={2765-9}
}
We have previously characterized an infectious mouse mammary tumor virus [(MMTV(SW)] which induces a strong superantigen response in vivo. Here we describe the isolation and characterization of MMTV(C4) which was derived from milk of mice implanted with hyperplastic alveolar nodules. MMTV(C4) stimulates V beta 2 expressing T cells after local injection in vivo. Comparison with known open reading frame (orf) sequences revealed high homology to Mtv-6, an endogenous virus interacting with V beta 3… CONTINUE READING