A new incomplete-repair model based on a 'reciprocal-time' pattern of sublethal damage repair.

@article{Dale1999ANI,
  title={A new incomplete-repair model based on a 'reciprocal-time' pattern of sublethal damage repair.},
  author={Roger G. Dale and John F. Fowler and Bradley. Jones},
  journal={Acta oncologica},
  year={1999},
  volume={38 7},
  pages={919-29}
}
A radiobiological model for closely spaced non-instantaneous radiation fractions is presented, based on the premise that the time process of sublethal damage (SLD) repair is 'reciprocal-time' (second order), rather than exponential (first order), in form. The initial clinical implications of such an incomplete-repair model are assessed. A previously derived linear-quadratic-based model was revised to take account of the possibility that SLD may repair with time such that the fraction of an… CONTINUE READING
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