A new in vitro model to test the effectiveness of topical antimicrobial agents. Use of an artificial eschar.

@article{HerruzoCabrera1992ANI,
  title={A new in vitro model to test the effectiveness of topical antimicrobial agents. Use of an artificial eschar.},
  author={Rafael Herruzo-Cabrera and M. J. Vizca{\'i}no-Alcaide and Richard F. Mayer and Juan del Rey-Calero},
  journal={Burns : journal of the International Society for Burn Injuries},
  year={1992},
  volume={18 1},
  pages={35-8}
}
An in vitro method using a burn eschar 'equivalent' is described to compare the efficacy of several antimicrobial creams. Fragments of lyophilized pigskin were used as 'germ carriers' and after 24 h of treatment the effectiveness of the antimicrobial creams was tested through the evaluation of bacterial recovery both from the surface and from within the 'germ carriers'. The results showed a striking full skin thickness effectiveness of 0.5 per cent chlorhexidine, 10 per cent providone iodine… CONTINUE READING