A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes.

@article{Suzuki1996ANI,
  title={A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes.},
  author={Seiichi Chiyoda-ku Suzuki and Xiao-Kang Li and Shin Enosawa and Takashi Shinomiya},
  journal={Immunology},
  year={1996},
  volume={89 4},
  pages={
          518-23
        }
}
FTY720 is a unique immunosuppressive drug produced by modification of a metabolite from Isaria sinclairii. In vitro treatment of human mononuclear cells with FTY720 resulted in a dose-dependent reduction of cell viability. These treated cells demonstrated characteristic DNA ladder formation on agarose gel electrophoresis. Jurkat cells transfected with human bcl-2 gene were resistant to FTY720; their neo type was susceptible to the drug. A rapid acceleration of cell death in human mononuclear… CONTINUE READING
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