A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy.

@article{Choi2009ANI,
  title={A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy.},
  author={William W. L. Choi and Dennis D. Weisenburger and Timothy C Greiner and Miguel {\'A}ngel Piris and Alison H Banham and Jan Delabie and Rita M. Braziel and Huimin Geng and Javeed Iqbal and G. Lenz and Julie Marie Vose and Christine P. Hans and Kai Fu and Lynette M Smith and Min Li and Zhongfeng Liu and Randy D. Gascoyne and Andreas Rosenwald and German Ott and Lisa M Rimsza and El{\'i}as Campo and Elaine S. Jaffe and David L Jaye and Louis M Staudt and Wing Chung David Chan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 17},
  pages={
          5494-502
        }
}
PURPOSE Hans and coworkers previously developed an immunohistochemical algorithm with approximately 80% concordance with the gene expression profiling (GEP) classification of diffuse large B-cell lymphoma (DLBCL) into the germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes. Since then, new antibodies specific to germinal center B-cells have been developed, which might improve the performance of an immunostain algorithm. EXPERIMENTAL DESIGN We studied 84 cases of… CONTINUE READING

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