A new hypothesis of tumorigenesis induced by biomaterials: inhibitory potentials of intercellular communication play an important role on the tumor-promotion stage.


A possible mechanism of tumorigenesis induced by the polyetherurethanes (PEUs) is clarified as follows: the tumor-promoting activities of the PEUs were stronger than the initiating activities; the promotion was facilitated by the polyether soft segment moiety such as poly (tetramethylene oxide) (PTMO), resulting in the inhibition of the gap-junctional… (More)


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