A new hybrid semantic similarity computation method based on gene ontology

@article{Liu2014ANH,
  title={A new hybrid semantic similarity computation method based on gene ontology},
  author={Lizhen Liu and Xuemin Dai and Chao Du and Hanshi Wang and Jingli Lu},
  journal={2014 IEEE 5th International Conference on Software Engineering and Service Science},
  year={2014},
  pages={849-853}
}
Most existing methods used for computing semantic similarity don't take full consideration of related factors, therefore they not only fail to handle identical annotations but also show a strong bias toward well-annotated gene or gene products. Concerning these problems, we proposed a new hybrid method based on multiple factors that affect the semantic similarity of Gene Ontology (GO) terms. The new method integrated information content and the structure of GO to compute the semantic similarity… CONTINUE READING
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