A new hyaluronic acid pH sensitive derivative obtained by ATRP for potential oral administration of proteins.

Abstract

Atom transfer radical polymerization (ATRP) has been successfully employed to obtain a new derivative of hyaluronic acid (HA) able to change its solubility as a function of external pH and then to be potentially useful for intestinal release of bioactive molecules, included enzymes and proteins. In particular, a macroinitiator has been prepared by linking 2… (More)
DOI: 10.1016/j.ijpharm.2013.09.005

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@article{Fiorica2013ANH, title={A new hyaluronic acid pH sensitive derivative obtained by ATRP for potential oral administration of proteins.}, author={Calogero Fiorica and Giovanna Laura Pitarresi and Fabio Palumbo and Mauro Di Stefano and Filippo Calascibetta and Gaetano Giammona}, journal={International journal of pharmaceutics}, year={2013}, volume={457 1}, pages={150-7} }