A new human monoclonal cold agglutinin Sa recognizing terminal N-acetylneuraminyl groups on the cell surface.

@article{Roelcke1980ANH,
  title={A new human monoclonal cold agglutinin Sa recognizing terminal N-acetylneuraminyl groups on the cell surface.},
  author={Dieter Roelcke and Waldemar Pruzanski and Werner Ebert and Wolfgang R{\"o}mer and Eva M. Fischer and Volker Lenhard and Ernst W. Rauterberg},
  journal={Blood},
  year={1980},
  volume={55 4},
  pages={677-81}
}
A human homogeneous IgM/K cold agglutinin (CA) Sa is described, whose corresponding antigen on erythrocytes (RBC) was abolished by neuraminidase. This indicated that the antigen was related to N-acetylneuraminic acid, similar to Pr and Gd antigens. In contrast, this antigen was only partially destroyed by proteases, whereas Pr antigens are completely destroyed and Gd antigens are not influenced by proteases. Sa antibody activity was inhibited by sialyllactose NeuAc (alpha 2 leads to 3) (alpha 2… CONTINUE READING