A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

@article{Kamps1990ANH,
  title={A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.},
  author={Mark P. Kamps and Cornelis Murre and Xing Huai Sun and David Baltimore},
  journal={Cell},
  year={1990},
  volume={60 4},
  pages={547-55}
}
It was previously shown that the chromosome 19 breakpoint of the t(1;19)(q23;p13.3) translocation, found in human pre-B cell acute lymphoblastic leukemias, is within the E2A transcription factor gene on chromosome 19. A cell line with this translocation contains two novel chimeric mRNAs, both with the same 5'E2A sequences but with different lengths of 3' sequence from a previously unrecognized gene dubbed prl, located on chromosome 1. The chimeric RNAs encode a protein that lacks 171 amino… CONTINUE READING

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