A new hamster model for adenoviral vaccination

  title={A new hamster model for adenoviral vaccination},
  author={Richard N. Hjorth and Geraldine M. Bonde and Walter Pierzchala and Steven K. Vernon and F. P. Wiener and Mark H. Levner and Michael D. Lubeck and Paul P. Hung},
  journal={Archives of Virology},
Both adult and baby hamsters infected intranasally with human adenovirus type 5 exhibited virologic, serologic, and histologic evidence of infection. When 8-day old hamsters were infected with 4×106 pfu, concentrations of virus up to 2×106 pfu/animal were detected in the lung, peaking on day 2. The minimum infectious dose was 1×103 pfu/animal. This model may be useful in studies of conventional and recombinant adenoviral vaccines for humans. 

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 11 extracted citations


Publications referenced by this paper.
Showing 1-10 of 11 references

In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses

  • A Ballay, M Leurero, MA Buendia, P Tiollais, M Perricaudet
  • EMBO J
  • 1985
1 Excerpt

Studies of the adenoidal-pharyngeal-conjunctival (APC) group of viruses

  • WP Rowe, RJ Huebner, JW Hartley, TG Ward, RH Parrott
  • Am J Hyg
  • 1955
1 Excerpt

Similar Papers

Loading similar papers…