A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

@inproceedings{Sala2016ANH,
  title={A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells},
  author={Luca Sala and Zhiyi Yu and Dorien Ward-van Oostwaard and Jacobus P D van Veldhoven and Alessandra Moretti and Karl-Ludwig Laugwitz and Christine L Mummery and Adriaan P. IJzerman and Milena Bellin},
  booktitle={EMBO molecular medicine},
  year={2016}
}
Long-QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms of LQTS, while the acquired form, often triggered by drugs that (sometimes inadvertently) target the cardiac hERG channel, is still a challenge in drug development because of cardiotoxicity. Current experimental models in vitro fall short in predicting… CONTINUE READING
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