A new glycoengineered insect cell line with an inducibly mammalianized protein N-glycosylation pathway.

Abstract

The inability to produce recombinant glycoproteins with authentic N-glycans is a limitation of many heterologous protein expression systems. In the baculovirus-insect cell system, this limitation has been addressed by glycoengineering insect cell lines with mammalian genes encoding protein N-glycosylation functions ("glycogenes") under the transcriptional… (More)
DOI: 10.1093/glycob/cwr160

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