A new genetic locus controlling growth and proliferation in Drosophila melanogaster.

@article{Raisin2003ANG,
  title={A new genetic locus controlling growth and proliferation in Drosophila melanogaster.},
  author={Sophie Raisin and Sophie Pantalacci and J P Breittmayer and Pierre L{\'e}opold},
  journal={Genetics},
  year={2003},
  volume={164 3},
  pages={1015-25}
}
Multicellular organisms grow through both proliferation and growth of their individual cells. We have conducted a P-element-based misexpression screen for genes whose upregulation alters wing disc growth during development. One particular group of four P elements, all inserted at cytological location 61C7-8, exhibited specific overgrowth upon misexpression in proliferating imaginal tissues. Clonal analysis revealed that upon misexpression, cell number was increased but cell size was not… CONTINUE READING